Comorbidity burden and neuropathology Lead Investigator: Sujuan Gao Institution : Indiana U E-Mail : sgao@iu.edu Proposal ID : 905 Proposal Description: Many elderly subjects suffer from multiple comorbidities before being diagnosed with Alzheimer's disease. The objective of this analysis is to examine whether specific comorbid conditions and an overall higher comorbidity burden are associated with (1) different cognitive decline trajectory and (2) AD neuropathology.